After many hours of work over the past year+, I finally have a new way to create GRASS binaries for the Mac. This is due in a large part to the help of Eric Hutton at the Community Surface Dynamics Modeling System (CSDMS) at U Colorado.
These new binaries, built with Anaconda, bundle all dependencies inside the *app, including Python and wxPython. They should be much more robust at avoiding conflicts with other versions of dependency programs you may have installed (e.g., gdal, Python, or wxPython). You do NOT need to install any frameworks for these to work, and they ignore any frameworks you have installed. Also, they do not seem to have any problem running with Apple's System Integrity Protection enabled.
Take them for a spin. I do not know which OS X version can run them. Hopefully all recent ones. Ultimately, I'll be archiving all older versions of GRASS, except the legacy pre-OSX 10.8 versions and replacing them with the new ones.
With Eric's help, there may also be an Anaconda package of GRASS in the future, for those who use that environment.
Cheers
Michael